Tirzepatide

Document SDS-VHL-TIRZEPATIDE | Version 1.0 | Issued 6 September 2026 | Supersedes None | Review Annually

Substance Identity

CAS No.: 2023788-19-2
Molecular formula: C225H348N48O68
Molecular weight: 4813 g/mol
Appearance: White to off-white lyophilized powder
Purity: ≥ 99% (RP-HPLC), per batch Certificate of Analysis

GHS Classification

Classification: Not classified as a hazardous substance or mixture under OSHA HazCom 2012 (29 CFR 1910.1200) / GHS.
Signal word: None
Pictograms: None required
Hazard statements: None

Not meeting GHS classification criteria is not the same as being known to be safe. Toxicological properties have not been fully investigated. Handle under Good Laboratory Practice, see Sections 7 and 8.

Download / print this SDS Batch Certificates of Analysis

1Identification

Product identifier: Tirzepatide — research chemical, lyophilized powder
Synonyms: LY3298176; GIP/GLP-1 dual agonist
Product code: SDS-VHL-TIRZEPATIDE
Recommended use: Research Use Only (RUO) — laboratory research, analytical and scientific applications.
Uses advised against: Not for human or veterinary use. Not a drug, food, cosmetic, dietary supplement or household product. Not for diagnostic or therapeutic use.
Supplier: Vertex Enterprise Partners LLC · Miami, FL 33132, USA · vertexhealthlabs.com
Emergency telephone: U.S. Poison Control Center: 1-800-222-1222 (24 hour). For chemical spill or transport emergencies, contact your regional emergency-response service.

2Hazard(s) Identification

GHS classification: Not classified as a hazardous substance or mixture per OSHA HazCom 2012 (29 CFR 1910.1200) / GHS.
Signal word: None
Pictograms: None required
Hazard statements: None
Precautionary (GLP): P262 avoid eye, skin and clothing contactP270 no eating, drinking or smoking when handlingP280 wear gloves and eye protectionP501 dispose per regulations
Other hazards: Toxicological properties have not been fully investigated. May be harmful if inhaled, swallowed, or absorbed through skin. Avoid forming or inhaling dust. Not assessed as PBT or vPvB.

3Composition / Information on Ingredients

Substance type: Single substance (synthetic peptide)
Chemical name: Tirzepatide (LY3298176; GIP/GLP-1 dual agonist)
CAS No. / EC No.: 2023788-19-2 / not assigned
Molecular formula: C225H348N48O68 · MW 4813 g/mol
Concentration: ≥ 99% (RP-HPLC); balance residual synthesis salts and moisture
Hazardous impurities: None present at reportable concentrations.

4First-Aid Measures

Inhalation: Move the person to fresh air and keep them comfortable for breathing. If breathing has stopped, give artificial respiration. Get medical attention if symptoms occur.
Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Get medical attention if irritation develops or persists.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do, then continue rinsing. Get medical attention if irritation persists.
Ingestion: Rinse mouth. Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Get medical attention.
Symptoms and effects: No specific data available; symptoms of overexposure are not established.
Note to physician: Treat symptomatically. Contact U.S. Poison Control (1-800-222-1222).

5Fire-Fighting Measures

Suitable media: Water spray, dry chemical, carbon dioxide (CO₂) or alcohol-resistant foam.
Unsuitable media: None known.
Special hazards: Thermal decomposition may release carbon oxides (CO, CO₂) and nitrogen oxides (NO_x).
Advice for firefighters: Wear self-contained breathing apparatus (SCBA) and full protective equipment.

6Accidental Release Measures

Personal precautions: Wear appropriate PPE (Section 8). Avoid dust formation and inhalation. Ensure adequate ventilation.
Environmental precautions: Prevent entry into drains, waterways and soil.
Containment and cleanup: Collect using dust-suppressing methods and place in a sealed, labelled container for disposal. Avoid generating airborne dust. Clean the affected surface after removal.

7Handling and Storage

Safe handling: Use only in a well-ventilated area or under a fume hood or laminar-flow enclosure. Wear PPE. Avoid contact with skin, eyes and clothing; avoid inhalation and ingestion. Follow Good Laboratory Practice. Wash hands thoroughly after handling.
Storage conditions: Store the lyophilized powder tightly sealed at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted solutions; prepare fresh and store cold. Keep away from incompatible materials (Section 10).
Shelf life: Per batch Certificate of Analysis. Verify the lot at vertexhealthlabs.com/coa.

8Exposure Controls / Personal Protection

Exposure limits: No occupational exposure limits (OEL, PEL or TLV) have been established for this substance.
Engineering controls: Adequate general ventilation; handle under a fume hood where dust may be generated. Provide accessible eyewash station and safety shower.
Eye and face: Safety glasses or goggles (ANSI Z87.1 / EN166).
Skin and body: Nitrile gloves; laboratory coat.
Respiratory: If dust is generated, wear a NIOSH-approved N95 or better respirator.

9Physical and Chemical Properties

Appearance: White to off-white lyophilized powder (solid)
Physical state: Solid
Odour: Odourless
pH: No data available (dilute aqueous ≈ neutral)
Melting point: No data available
Boiling point: Not applicable (decomposes)
Flash point: Not applicable
Flammability: Not flammable
Vapour pressure: Negligible
Solubility: Soluble in water and aqueous buffers; soluble in DMSO
Log P<sub>ow</sub>: No data available
Autoignition: No data available
Decomposition temp.: No data available
Molecular formula: C225H348N48O68
Molecular weight: 4813 g/mol

10Stability and Reactivity

Reactivity: Not reactive under normal conditions of use and storage.
Chemical stability: Stable as a lyophilized powder under recommended storage. Reconstituted solutions are less stable; keep cold and use promptly.
Hazardous reactions: None known; will not undergo hazardous polymerization.
Conditions to avoid: Heat, moisture, direct light and repeated freeze-thaw cycles.
Incompatible materials: Strong oxidizing agents; strong acids and bases.
Decomposition products: Carbon oxides (CO, CO₂) and nitrogen oxides (NO_x) on thermal decomposition.

11Toxicological Information

Acute toxicity: No data available — LD₅₀ / LC₅₀ not determined
Skin corrosion / irritation: No data available
Eye damage / irritation: No data available
Sensitization: No data available
Mutagenicity: No data available
Carcinogenicity: Not listed by IARC, NTP or OSHA.
Reproductive toxicity: No data available
STOT / aspiration: No data available

Supplied for research use only. Toxicological properties have not been thoroughly investigated. Handle as a substance of unknown toxicity.

12Ecological Information

Ecotoxicity: No data available
Persistence / degradability: No data available
Bioaccumulation: No data available
Mobility / PBT: Not assessed — avoid release to the environment.

13Disposal Considerations

Waste treatment: Dispose of contents and container in accordance with local, state and federal regulations. Do not discharge into drains, waterways or the environment. Where required, use a licensed waste-disposal contractor.
Contaminated packaging: Dispose of as unused product.

14Transport Information

DOT / IATA / IMDG: Not regulated as dangerous goods.
UN number: None
Proper shipping name: Not applicable
Hazard class / PG: None / None
Environmental hazards: None known
Special precautions: Maintain cold chain during transport where required to preserve product integrity.

15Regulatory Information

Product status: Research Use Only (RUO). Not approved by the U.S. FDA. Not intended for human or veterinary use, nor for use as a drug, food, dietary supplement, cosmetic or household product.
TSCA (US): Used for research and development; not for general commercial distribution as a chemical substance.
SARA 311/312: No applicable hazard categories
California Prop 65: No listed components known to the State of California to cause cancer or reproductive harm.
Standard applied: Prepared in accordance with OSHA HazCom 2012 (29 CFR 1910.1200) and GHS.

16Other Information

Date of issue: 6 September 2026 · Version 1.0 · Supersedes: None
Data source: CAS number, molecular formula and molecular weight from PubChem (NIH), CID 166567236.
Abbreviations: GHS Globally Harmonized System · RUO Research Use Only · GLP Good Laboratory Practice · OEL/PEL/TLV Occupational Exposure Limit / Permissible Exposure Limit / Threshold Limit Value · PBT/vPvB Persistent-Bioaccumulative-Toxic / very Persistent very Bioaccumulative · SCBA Self-Contained Breathing Apparatus · No data = information not available.

For Research Use Only. Not for human consumption. Not evaluated by the FDA; not intended to diagnose, treat, cure or prevent any disease. Must be 21 or older to purchase.

Disclaimer. The information in this Safety Data Sheet is provided in good faith and believed to be accurate as of the date of issue. It relates only to the specific material identified and to research-use conditions; it may not be valid if the material is used in combination with any other material or in any process not described here. Because conditions of use are outside our control, Vertex Enterprise Partners LLC makes no warranty, express or implied, and assumes no liability in connection with any use of this information. The user is responsible for determining suitability and for ensuring safe handling, storage and disposal in compliance with all applicable laws. This document is not a specification; batch-specific data is provided on the Certificate of Analysis.